3 dogs laying on the grass

Hearing that your dog has cancer can feel overwhelming. At CTAC, we understand the difficult emotions that come with this diagnosis, and we’re here to help you explore every option available. If a Stem Cell Transplant (SCT) is something you’re considering, it’s important to contact our team as soon as possible.

1

Diagnosis

We will work closely with your veterinarian to ensure your dog is properly prepared for SCT. This may include adjustments to their current cancer treatment plan to align with the transplant protocol. Our goal is to provide a seamless, supportive experience as you navigate this challenging journey with your beloved companion.

2

Initial consultation

After reaching out to CTAC, you will have an initial consultation with our oncologist, who will guide you through every step of the process. If a donor is needed, we’ll discuss the potential options.

Following this consultation, you and the oncologist will decide together whether pursuing the transplant is the best path for your dog.

3

Before admission

Before beginning the SCT process, your dog will need a high dose of cyclophosphamide (chemotherapy) to help eliminate as many cancer cells as possible and to prepare its body before stem cell collection. This treatment is typically administered about two weeks prior to admission at CTAC and can be coordinated through your local oncologist.

4

Pre-transplant evaluation

Your dog will undergo a comprehensive evaluation to ensure they are healthy enough for the procedure. This includes:

  • Diagnostic testing to check if the cancer is in remission
  • Ruling out disease or other systemic issues
  • Assessing organ function to ensure there is no damage from prior treatments

These tests can be performed locally or at CTAC upon arrival.

5

Informed consent conference

At the time of your dog’s admission, you and your family will participate in an informed consent conference with the oncologist.

  • Review the results of the pre-transplant evaluation
  • Discuss the treatment plan in detail
  • Outline the benefits and risks of the procedure

This is an important opportunity to ensure you fully understand every aspect of the transplant process and have all your questions answered.

6

Admission to CTAC & treatment

If your dog is receiving an autologous transplant, they will need to arrive at CTAC five days before stem cell collection. For allogeneic transplants, both your dog and the matched donor will be admitted, with the donor typically able to return home the same day or the following day after stem cell collection.

  • Stem cell collection is performed using a process called leukapheresis, where blood is drawn and passed through an apheresis machine to isolate the stem cells
  • Once collected, your dog will undergo total body irradiation (TBI) administered by our radiation oncologist

Immediately following radiation therapy, the harvested stem cells are transplanted through an IV catheter by our radiation oncologist, with the goal of killing all the cancer cells in your dogs body (autologous) or making space for the donor cells (allogeneic).

7

After the transplant

Within hours of the transplant, the newly transplanted stem cells will travel to the bone marrow and begin the process of engraftment.

  • It typically takes about two (autologous) or three (allogeneic) weeks for the new bone marrow to start producing red blood cells, white blood cells, and platelets, which are essential for your dog's recovery
  • Your dog will stay in a controlled environment to reduce the risk of infection
  • Our team will administer antibiotics and other supportive medications as needed

To prioritize your pet’s safety, visits can be discussed, but access will be restricted for the first week or so before becoming less limited. If in person visits are determined to be too high of a risk, we can facilitate virtual visits for you to check up on your pet. You can feel confident knowing they are being carefully monitored and lovingly cared for.

8

Leaving the hospital

Once your dog is cleared to go home, they will still require rest to support their full recovery. Follow-up care includes regular blood work rechecks with your primary veterinarian to monitor progress and ensure a smooth recovery. Our team will provide detailed instructions to help your dog transition safely back to their home environment.

At CTAC, we’re committed to providing the highest level of care and support for both you and your dog throughout the SCT process. If you’re ready to take the next step or simply want to learn more about how we can help, our team is here to answer your questions and guide you every step of the way.